Well, I did not do it in a day, not that there is anything wrong with it.........oooops, wrong subject. It took me 7 hours to get to Morro Bay, which includes a lunch and sight seeing. We stayed in Morro Bay overnight and then headed north on Hwy 1 through Cambria, San Simeon, Big Sur, Monterrey and eventually made it up to SF, that took all day, but well worth it.
Hairball, the route you're taking is great. Make sure that you know your way through Lompoc because Hwy 1 just drops you off in front of the Home Depot and then it's surface streets through Lompoc. You catch Hwy 1 from F Street, which turns into Hwy 1. This will take you toward Guadalupe and Santa Maria. Last weekend my wife and I did this route to Santa Maria. Make sure you have lunch or dinner at Jocko's in the town of Nipomo, just 5 miles north of Santa Maria. Good luck and have fun.